LDL Cholesterol Too High?

Atherogenesis

The supposed ability of fish oil affect cardiovascular health attention has considerable nutritional status of lipids. Research on companies with high levels of consumption of omega-3 and -9 oils as well as prospective and retrospective studies have demonstrated the growing importance of dietary fats.1-6 complex mechanisms have been theorized but ultimately dependent on eicosanoid synthesis pathways. Fatty acids and other fatty substances such as cholesterol in the circulation and as part of the endothelial lining of blood vessels and smooth muscle layer, and platelets, provide an important substrate for vascular health or disease.

PLATELETS
Platelets play a central role in the relationship between lipids and atherogenesis. Platelets are potent biochemical packages wrapped in a membrane of phospholipids. When platelets in the circulation are exposed to the vessel endothelial lining fabric broken blood and the underlying collagen. are activated to stimulate wound healing.

Arachidonic acid in platelets form two eicosanoids different, serving both functions. If the plate is adjacent to another of platelet thromboxane (TXA2) is formed (500 million platelets can form 2 mg of thromboxane), which stimulates aggregation and coagulation of blood platelets and platelets other components.7 For those who are close to the endothelium, prostaglandin E2 (PGE2) is formed which stimulates hyperplasia of blood vessels exposed tissues and inhibits clotting more closely to the injury. Prostaglandins also stimulate bone resorption Calcium is the site of the lesion to reduce the pH of the tissues and further stimulate hyperplasia.

These are the normal mechanisms are continually and are essential for life. If you do not have occurred, minor vascular lesions can cause bleeding in the flight, and the healing and repair would not occur. However, when there is excess omega-6 fatty acids in platelets that can lead to excessive amounts of arachidonic acid sites of blood vessel injury, blood vessels constrict, blood clotting, bone resorption and hyperplastic effects may be greater than the fight against moderating effects of prostaglandins from fatty acids such as omega-3.

PATHOGENESIS
High levels of fat in the diet can cause high levels of lipoprotein density (LDL). These lipid-protein complexes may contain large amounts of cholesterol, many of which can be oxidized because of the way modern food is processed.8 LDL can migrate to areas of injury, being engulfed by monocytes and macrophages, and accumulate at the site of these injuries to provide more arachidonic acid and fuel generator of free radicals oxidize cholesterol endothelium of further damage.

This series of courses, starting perhaps with a small lesion which is presented as a matter of course in the endothelium, or the damage induced by elevated blood levels of oxidized fat, can become a self-sustaining, outside control, growth cancerlike accumulating in vessels resulting in atheroma and eventual closure of the coronary vessels leading to a heart attack. In addition, the hardening (Sclerosis) arteries can lead to hypertension and loss of vascular resistance, which can cause stroke, aneurysm, general loss of health and vigor, and predisposition to a variety of other diseases.

In other words, if vascular injury, coagulation constriction, vessels, machinery regeneration of tissues may spin out of control due to the moderate e1cosanoids imbalance resulting from dietary fat. The excess tissue with a potential cascade arachidonic vascular injury recruits excess platelets, which stimulate excessive clotting constriction, vessel and inflammation of the vessel wall

[Atherosclerosis] Image Sequence
http://www.wysong.net/articles/lipid/figures/figure26.jpg

which in turn releases more arachidonic cascade eicosanoids, Besides stimulating aggregation, platelets, clotting and so on, leading to atheroma and vascular occlusion.

If no injury Endothelial, but induced oxidative elevated blood levels of lipids, a similar cycle occurs. The oxidized LDL is trapped by the monocytes into macrophages, that accumulate in the vessel wall that causes free radical damage, foam cell formation, calcium deposition and inflammation. This product metabolites arachidonic cascade, which also induce inflammation that leads to atherosclerosis and the gradual closure of the vessels. (Fig. 26, 27)

BACKGROUND PREVENTION
A change in diet, such as oxidized fats are reduced, reducing saturated fats, omega-6 is reduced (in Western societies) and omega-3 and omega-9 rich foods are increasing, which could lead to a healthy recovery in the vessel wall. Prostaglandins formed by omega-3 and omega-9 oils to create opposite effects on vessel constriction, forming a clot effects of omega-6 as they compete for the same enzyme system. (See fig. 18) Therefore, if omega-3 and -9 fatty acids in the diet increases, using the enzyme systems normally used acid to form eicosanoids promotion byarachidonic atherogenic. It is the current explanation of the epidemiological evidence that shows that humans and animals consuming high levels of omega-3 and omega-9 classes acids of developing cardiovascular problems much less common than those in Western society.

There is some evidence that the incidence of the disease cardiovascular is proportional to the reports of different types of fatty acids in platelets, which in turn is related to food. Eskimos, for example, have more omega-3 and the ratio of omega-6 fatty acids in their tissues that reflect their diet of fish for human consumption high, which in turn is associated with low risk of disease cardiovascular disease compared with Western countries. (Fig. 28)

[The formation of atheroma Image]
http://www.wysong.net/articles/lipid/figures/figure27.jpg

This does not mean that the omega-6 fatty acids such as linoleic are harmful in itself. Balance is the key. In fact, if this is not enough linoleic, the Atherosclerosis can lead, as evidenced by a series of species.9, 10

ASPIRIN
By changing the balance of these enzyme systems eicosanoids aspirin also is believed to exert its anti-clotting agent effect on cardiovascular disease. Aspirin is a specific inhibitor (acetyl), cyclooxygenase that is normally used to convert arachidonic acid to TXA2 and PGE2. inhibition of TXA2 aspirin clotting is the formation of several days and its effect on anticoagulant and vasodilator PGE2. Thus, the net effect is inhibition of coagulation. (See fig. 19)

[Comparison of food oil / bold] Image Composition
http://www.wysong.net/articles/lipid/figures/figure28.jpg

However, aspirin is a bandage. It does not address the root, which is reprehensible food. It is not safe because it can trigger allergic reactions such as asthma by shunting arachidonic acid lipoxygenase and leukotriene pathway may actually increase clotting of platelets when administered in conjunction with fish oils.11

Excessive consumption of fats and oxidized fatty acids omega-6 family run system atherosclerosis. surplus commodities may exceed the capacity of the moderators. If the cause is food, the final solution must also be food, non-pharmacological. What Ironically, 80 million tablets of aspirin taken daily by Americans largely may be necessary to neutralize the effects of 15 million pounds of omega-6 polyunsaturated oils predominantly processed.

NUTRIENTS
Many nutrients found in foods have the ability to block or modulate prostaglandin synthesis. These include compounds of sulfur in the onion, garlic and cruciferous vegetables, and several minerals, including divalent cations zinc, copper, lithium, silver, selenium and calcium.12 A variety of fresh whole (first if possible) grown in nutrient-rich soils (as opposed to modern agribusiness extracted soils where nitrogen phosphorus and potassium only – NPK – are replaced) provides the body with raw materials that improve nutrition and fatty acids may reduce or avoid use of potentially dangerous drugs.

Other non-pharmacological factors that can help produce more "friendly lipid profiles" includes stress reduction, increased exercise and the elimination of snuff, and perhaps very caffeine.13 refined carbohydrates and sugar diets increase disease risk cardiovascular reactions may be due to glycosylation, increased lipoprotein (a) levels and decreased HDL levels.14 Calcium 800 mg a day can reduce Chrome cholestero1.15 deficit factor may decrease glucose tolerance and therefore affect the metabolism of sugars and lipids affect proflies.16Legumes, soluble fiber, the garlic and onion can lower cholesterol levels.17 Vitamin C 1000 mg per day and vitamin E 200-400 IU per day, are antioxidants and may reduce the excellent glycosylation reaction, the rate of decrease and increase HDL cholesterol, 18 Pantethine, a derivative of pantothenic acid 300 mg. 3-4 times a day, 19 and niacin 1-4 grams per day may influence positive lipids. Niacin is actually one of the few players capable of genetically controlled lower Lp (a levels.20) L-carnitine, an amino acid, 1000 mg per day can improve hyperlipoproteinemia.21

These nutrients are supplied in a varied diet of whole foods first. Some researchers contend, without however, that therapeutic levels of certain nutrients are not available to mere consumption of natural foods. A deficit accumulated a lifetime of overeating may in fact need a boost. The disease, an extraordinary event, may require extraordinary measures for a cure. But before consuming all aware of his isolated nutrients advantages and disadvantages and that some nutrients may have toxic effects or imbalances in certain levels. In the nutrition guidance of a qualified health professional is recommended for people with existing disease you want to use isolated nutrients in therapy.

As mentioned in the previous chapter, in the case of relationship between diet and heart disease is not closed. Some argue that the assumption of power began heart, remains, and grows with the support of powerful institutions and giant personalities promote health and disease and food industries.22 Some have estimated that 20-62 people with a continuous program of cholesterol reduction may increase the life span of three days for thirty months.23 Even Sir William Osler, the most highly respected doctor at the time, said in 1879 that degeneracy pressure can occur even at an early age and is due to "high pressure in which men live, and work habits of the machine to its maximum capacity," not to overeating and drinking. 24

No doubt that singular focus on diet or exercise, for example, misses the target. Ignores equally important factors as self-esteem, relationships of affection and feeling in control of his life.25 The controversy aside, living and eating more natural synergonic and it can only help probably the greatest potential for disease-free life.

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About the Author

Dr. Wysong: A former veterinary clinician and surgeon, college instructor in human anatomy, physiology and the origin of life, inventor of numerous medical, surgical, nutritional, athletic and fitness products and devices, research director for the present company by his name and founder of the philanthropic Wysong Institute. http://www.wysong.net. Also check out http://www.cerealwysong.com.

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